This summary table contains detailed information about research studies. Summary tables offer an informative look at the science behind many breast cancer guidelines and recommendations. However, they should be viewed with some caution. In order to read and interpret research tables successfully, it is important to understand some key concepts. Learn how to read a research table.
Introduction: Adjuvant chemotherapy (chemotherapy after breast surgery) improves survival in women with breast cancer. Findings from a pooled analysis that combined data from 60 randomized clinical trials (that together included 28,764 women) showed women of all ages and different types of breast cancer can benefit from adjuvant chemotherapy. Women under age 50 showed the most improvement in 15-year overall survival.
The benefit of adjuvant chemotherapy depends on a person’s prognosis. People with the poorest prognosis get the most survival improvement, while those with the best prognoses get the smallest benefit.
Learn more about chemotherapy.
Learn about the strengths and weaknesses of different types of studies.
Study selection criteria: Early Breast Cancer Trialists' Collaborative pooled analysis.
Early Breast Cancer Trialists' Collaborative GroupPooled Analysis
Age and Prognosis
15-Year Overall Survival
Percent Surviving— Chemotherapy
Percent Surviving—No Chemotherapy
Absolute Improvement in Survival with Chemotherapy
By age at diagnosis
70 years or older
Among women <50 at diagnosis
Among women 50-69 at diagnosis
1. Early Breast Cancer Trialists' Collaborative Group. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 365(9472):1687-717, 2005.
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