| This summary table contains detailed information about research studies. While viewing summary tables offers an informative glimpse at the science behind many breast cancer guidelines and recommendations, they should be viewed with some caution. There are a number of concepts you must understand to be able to successfully read and interpret research tables. To get some background information about understanding research tables, please see How to Read a Research Table. |
Introduction: There are two types of the benign breast condition hyperplasia. In atypical hyperplasia, the dividing cells look abnormal under a microscope. With usual hyperplasia, the dividing cells look normal. As the cohort and nested case-control studies below show, both types of hyperplasia increase the risk of breast cancer, but atypical hyperplasia increases risk to a greater degree than usual hyperplasia does.
Find more information on the strengths and weaknesses of different types of studies.
See how this risk factor compares with other risk factors for breast cancer.
Study selection criteria: Available prospective cohort and nested case-control studies.
Table note: Relative risk above 1 indicates increased risk. Relative risk below 1 indicates decreased risk.
Study
|
Study Population
(number of participants)
|
Follow-up (years)
|
Relative Risk of Breast Cancer in Women with Hyperplasia
Compared to Women without Hyperplasia, by Specific Type,
RR (95% CI)
|
Usual Hyperplasia
|
Atypical Hyperplasia
|
Prospective cohort studies
|
Breast Cancer Prevention Trial-NSABP [1]
|
11,307
|
6.6
|
1.60 (1.17-2.19)
|
-
|
Mayo Benign Breast Disease Cohort [2]
|
9,376
|
13.7
|
-
|
3.88 (3.00-4.94)
|
Hartmann et al. [3]
|
9,087
|
15
|
1.88 (1.66-2.12)
|
4.24 (3.26-5.41)
|
| |
Study Population
(number of participants)
|
Relative Risk of Breast Cancer in Women with Hyperplasia
Compared to Women without Hyperplasia, by Specific Type, RR (95% CI)
|
Cases
|
Controls
|
Usual Hyperplasia
|
Atypical Hyperplasia
|
Nested case-control studies
|
Dupont et al. [4]
|
1,925
|
1,378
|
1.9 (1.2-2.9)
|
5.3 (3.1-8.8)
|
Nurses' Health Study and Nurses' Health Study II [5]
|
282
|
1,223
|
1.54 (1.12-2.11)
|
4.43 (2.93-6.69)
|
Breast Cancer Detection Demonstration Project [6]
|
95
|
190
|
1.3 (0.77-2.2)
|
4.3 (1.7-11.0)
|
Palli et al. [7]
|
62
|
315
|
1.3 (0.5-3.5)
|
13.0 (4.1-41.7)
|
References
1. Wang J, Costantino JP, Tan-Chiu E, et al. Lower-category benign breast disease and the risk of invasive breast cancer. J Natl Cancer Inst. 96(8):616-20, 2004.
2. Degnim AC, Visscher DW, Berman HK, et al. Stratification of breast cancer risk in women with atypia: a Mayo cohort study. J Clin Oncol. 25(19):2671-7, 2007.
3. Hartmann LC, Sellers TA, Frost MH, et al. Benign breast disease and the risk of breast cancer. N Engl J Med. 353(3):229-37, 2005.
4. Dupont WD and Page DL. Risk factors of breast cancer in women with proliferative breast disease. N Engl J Med. 312(3):146-151, 1985.
5. Tamimi RM, Byrne B, Baer H, et al. Benign breast disease, recent alcohol consumption, and risk of breast cancer: a nested case-control study. Breast Cancer Res. 7(4):R555-62, 2005.
6. Dupont WD, Parl FF, Hartmann WH, et al. Breast cancer risk associated with proliferative breast disease and atypical hyperplasia. Cancer. 71(4):1258-1265, 1993.
7. Palli D, Rosselli del Turco M, et al. Benign breast disease and breast cancer: a case-control study in a cohort in Italy. Int J Cancer. 47(5):703-705, 1991.
Updated 09/12/09
