One way to slow the growth of hormone receptor-positive breast cancer in premenopausal women is ovarian suppression.
Ovarian suppression uses drug therapy or surgery to prevent the ovaries from making estrogen.
This stops menstrual periods and lowers hormone levels in the body (similar to a natural menopause), so the tumor can't get the estrogen it needs to grow.
Ovarian suppression is only an option for premenopausal women.
It’s not helpful in postmenopausal women because their ovaries don’t make much estrogen after menopause.
Ovarian suppression drugs such as leuprolide (Lupron) or goserelin (Zoladex) can stop the ovaries from making estrogen.
In most cases, once drug therapy is stopped, the ovaries begin making estrogen again.
To learn more about a specific ovarian suppression drug, visit the National Institutes of Health’s Medline Plus website.
Surgical removal of the ovaries (oophorectomy) stops the production of estrogen and progesterone.
This permanently ends menstrual periods and leads to early menopause.
Learn more about early menopause and how to manage its symptoms.
Some younger, premenopausal women at high risk of breast cancer recurrence may benefit from treatment with ovarian suppression plus tamoxifen or an aromatase inhibitor [96-97].
Ovarian suppression alone is not a standard substitute for tamoxifen or an aromatase inhibitor.
Standard treatment for premenopausal women with hormone receptor-positive breast cancer is tamoxifen for 5-10 years, with or without ovarian suppression .
Aromatase inhibitors don’t normally work in premenopausal women because their ovaries are still making estrogen. Ovarian suppression shuts down the ovaries. So, premenopausal women may take an aromatase inhibitor for 5-10 years when combined with ovarian suppression .
Ovarian suppression combined with tamoxifen or an aromatase inhibitor causes more side effects from the loss of estrogen than the use of tamoxifen or an aromatase inhibitor alone [96-99].
Talk with your provider about whether ovarian suppression is right for you.
Some findings show ovarian suppression plus an aromatase inhibitor may reduce breast cancer recurrence better than ovarian suppression plus tamoxifen .
Some women at high risk of breast cancer recurrence who remain premenopausal after chemotherapy may be given ovarian suppression in combination with tamoxifen .
Among premenopausal women, some studies have found ovarian suppression drug therapy is as effective as chemotherapy in treating hormone receptor-positive breast cancer .
However, standard treatment for these breast cancers is tamoxifen, with or without chemotherapy.
Facts for Life: Hormone Therapy
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