This summary table contains detailed information about research studies. Summary tables are a useful way to look at the science behind many breast cancer guidelines and recommendations. However, to get the most out of the tables, it’s important to understand some key concepts. Learn how to read a research table.
Introduction: Tamoxifen improves survival for people with estrogen receptor-positive early breast cancer. It's a pill taken every day for 5-10 years.
Results from pooled analyses have shown tamoxifen use for 5 years increased overall survival in women with lymph node-negative tumors and those with lymph node-positive tumors [1-2].
The benefits of tamoxifen were not limited by a woman’s age or past treatment with chemotherapy.
Findings from a large randomized clinical trial showed taking tamoxifen for 10 years reduced the risk of breast cancer recurrence and death more than taking tamoxifen for 5 years .
Discuss the benefits and risks of taking tamoxifen for more than 5 years with your health care provider.
Learn more about tamoxifen.
Learn about the strengths and weaknesses of different types of studies.
Study selection criteria: Early Breast Cancer Trialists' Collaborative pooled analyses.
Early Breast Cancer Trialists' Collaborative GroupPooled Analyses [1-2]
15-Year Breast Cancer Survival*
Absolute Improvement in Survival with Tamoxifen
Tamoxifen use for 5 years
10-Year Overall Survival‡
15-Year Overall Survival‡
* Combined data from 20 randomized clinical trials that together included 21,457 women
† Statistically significant improvement
‡ Combined data from 44 randomized clinical trials that together included 33,209 women
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