Shiitake mushroom is a fungus. An extract made from this mushroom is used as medicine.
Shiitake mushroom is used for boosting the immune system, lowering blood cholesterol levels, treating prostate cancer, and as an anti-aging agent.
Shiitake mushroom is also eaten as food.
Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for SHIITAKE MUSHROOM are as follows:
More evidence is needed to rate the effectiveness of shiitake mushroom for these uses.
Shiitake mushroom is LIKELY SAFE when consumed by mouth in food amounts, but it seems POSSIBLY UNSAFE to take by mouth in medicinal amounts. It can cause stomach discomfort, blood abnormalities, and skin swelling (inflammation). It might also cause an increased sensitivity to the sun, allergic skin reactions, and breathing problems.
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking shiitake mushroom if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Shiitake mushroom might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using shiitake mushroom.
A blood disorder called eosinophilia: Don’t use shiitake mushroom if you have this condition. It might make eosinophilia worse.
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.
Shiitake mushroom seems to increase the immune system. By increasing the immune system, shiitake mushroom might decrease the effectiveness of medications that decrease immune system function.
Some medications that decrease immune system function include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
The appropriate dose of shiitake mushroom depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for shiitake mushroom. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Champignon Noir, Champignon Parfumé, Champignon Shiitake, Champignons Shiitake, Forest Mushroom, Hongos Shiitake, Hua Gu, Lenticus edodes, Lentin, Lentin des Chênes, Lentin du Chêne, Lentinan edodes, Lentinula, Lentinula edodes, Lentinus edodes, Mushroom, Pasania Fungus, Shitake, Shiitake, Snake Butter, Tricholomopsis edodes.
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. Except for any possible exceptions written into your License Agreement, no reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. Unlawful to download, store, or distribute content from this site.
For the latest comprehensive data on this and every other natural medicine, health professionals should consult the Professional Version of the Natural Medicines. It is fully referenced and updated daily.
© Copyright 1995-2019. Therapeutic Research Faculty, publishers of Natural Medicines, Prescriber's Letter, and Pharmacist's Letter. All rights reserved.
Discover the different ways you can help
1-877 GO KOMEN(1-877-465-6636)
Give hope to others in your situation