Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. It is used as a medicine.
Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. However, there is not strong evidence to support the use of resveratrol for these uses.
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The Effectiveness ratings for Resveratrol are as follows:
Possibly Effective for...
Possibly Ineffective for...
Insufficient Evidence to Rate Effectiveness for...
More evidence is needed to rate resveratrol for these uses.
Resveratrol might expand blood vessels and reduce the activity of cells important in blood clotting. Some research suggests that resveratrol has weak estrogen (a female hormone) effects. It may also decrease pain and swelling (inflammation).
When taken by mouth: Resveratrol is LIKELY SAFE when used in the amounts found in foods. When taken in doses up to 1500 mg daily for up to 3 months, resveratrol is POSSIBLY SAFE . Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. However, these higher doses of resveratrol are more likely to cause stomach problems.
When applied to the skin: Resveratrol is POSSIBLY SAFE when applied to the skin for up to 30 days.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Resveratrol is LIKELY SAFE when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol during pregnancy and breast-feeding.
Children: Resveratrol is POSSIBLY SAFE in children when sprayed in the nostrils for up to 2 months.
Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use resveratrol.
Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.
Some medications are changed and broken down by the liver. Resveratrol might decrease how quickly the liver breaks down some medications. Taking resveratrol along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking resveratrol, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include chlorzoxazone, theophylline, and bufuralol.
Some medications changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.
Some medications changed by the liver include theophylline, omeprazole, clozapine, progesterone, lansoprazole, flutamide, oxaliplatin, erlotinib, and caffeine.
Some medications changed by the liver include amitriptyline (Elavil), carisoprodol (Soma), citalopram (Celexa), diazepam (Valium), lansoprazole (Prevacid), omeprazole (Prilosec), phenytoin (Dilantin), warfarin, and many others.
Some medications changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and anesthetics such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), methoxyflurane (Penthrane).
Some medications changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and otherslovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Resveratrol might slow blood clotting. Using it along with other herbs or supplements that might also slow blood clotting could increase the risk of bleeding or bruising in some people. These herbs include angelica, clove, danshen, feverfew, garlic, ginger, ginkgo, ginseng Panax, horse chestnut, red clover, turmeric, and others.
There are no known interactions with foods.
The appropriate dose of resveratrol depends on several factors such as the user's age, health, and several other conditions. At this time, there is not enough scientific information to determine an appropriate range of doses for resveratrol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
3,5,4' TriHydroxy-Transstibene, (E)- 5-(4-hydroxystyryl)benzene-1,3-diol, 3,4',5-stilbenetriol, 3,5,4' -trihydroxystilbene, 3,4',5-trihydroxystilbene, 3,5,4'-trihydroxy-trans-stilbene, Cis-Resveratrol, Extrait de Vin, Extrait de Vin Rouge, Kojo-Kon, Phytoalexin, Phytoalexine, Phytoestrogen, Phyto-œstrogène, Pilule de Vin, Protykin, Red Wine Extract, Resvératrol, Resveratrols, Resvératrols, RSV, RSVL, Stilbene Phytoalexin, Trans-Resveratrol, Trans-Resvératrol, Wine Extract, Wine Pill.
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