Coenzyme Q10 is a vitamin-like substance found throughout the body, but especially in the heart, liver, kidney, and pancreas. It is eaten in small amounts in meats and seafood. Coenzyme Q10 can also be made in a laboratory.
Coenzyme Q10 is most commonly used for conditions that affect the heart such as heart failure, chest pain, and high blood pressure. It is also used for preventing migraine headache, Parkinson's disease, and many other conditions.
Coenzyme Q10 was first identified in 1957. The "Q10" refers to the chemical make-up of the substance.
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for Coenzyme Q10 are as follows:
More evidence is needed to rate coenzyme Q10 for these uses.
Coenzyme Q10 is an important vitamin-like substance required for the proper function of many organs and chemical reactions in the body. It helps provide energy to cells. Coenzyme Q10 also seems to have antioxidant activity. People with certain diseases, such as heart failure, high blood pressure, gum disease, Parkinson's disease, certain diseases of the muscles, and HIV infection, might have lower levels of coenzyme Q10.
Coenzyme Q10 is LIKELY SAFE for most adults when taken by mouth or when applied directly to the gums. While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. It can cause allergic skin rashes in some people. It also might lower blood pressure, so check your blood pressure carefully if you have very low blood pressure. Dividing the total daily dose by taking smaller amounts 2 or 3 times a day instead of a large amount all at once can help reduce side effects.
Coenzyme Q10 is POSSIBLY SAFE for children when taken by mouth. However, coenzyme Q-10 should not be used in children without medical supervision.
Pregnancy and breast-feeding: Coenzyme Q10 is POSSIBLY SAFE when taken by mouth appropriately during pregnancy. Coenzyme Q10 has been used safely when taken twice daily starting at 20 weeks until delivery. Not enough is known about the use of coenzyme Q10 during breast-feeding. Stay on the safe side and avoid use.
Chemotherapy: People undergoing chemotherapy with a class of drugs called alkylating agents should use coenzyme Q10 with caution. There is some concern that coenzyme Q10 might lower the effectiveness of these drugs. Some alkylating agents include busulfan, carboplatin, cisplatin, cyclophosphamide (Cytoxan), dacarbazine, thiotepa, and many others.
High blood pressure or low blood pressure: Coenzyme Q10 might lower blood pressure. It can increase the effects of medications used to lower blood pressure. Discuss your use of coenzyme Q10 with your healthcare provider if you have blood pressure problems.
Smoking: Cigarette smoking depletes the amount of coenzyme Q10 stored by the body.
Surgery: Coenzyme Q10 might interfere with blood pressure control during and after surgery. Stop using coenzyme Q10 at least two weeks before a scheduled surgery.
Interaction Rating = Minor Be watchful with this combination.
Talk with your health provider.
Doxorubicin is a chemotherapy medication used to treat different types of cancer. Doxorubicin might increase levels of coenzyme Q10 in the body. It is too soon to know if this interaction is important.
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.
Coenzyme Q10 is an antioxidant. There is some concern that antioxidants might decrease the effectiveness of some medications used for cancers. But it is too soon to know if the interaction occurs. Some medications for cancer include busulfan, carboplatin, cisplatin, cyclophosphamide (Cytoxan), dacarbazine, thiotepa, and many others.
Coenzyme Q10 seems to decrease blood pressure. Taking coenzyme Q10 along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Warfarin (Coumadin) is used to slow blood clotting while coenzyme Q10 might increase blood clotting. By helping the blood clot, coenzyme Q10 might decrease the effectiveness of warfarin (Coumadin) and increase the risk of dangerous clots. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
Taking coenzyme Q10 with acacia gum seems to increase the body's absorption of coenzyme Q-10. In theory, this might increase the effects and side effects of coenzyme Q10.
Coenzyme Q10 can increase blood levels of beta-carotene. In theory, this might increase the effects and side effects of beta-carotene.
Coenzyme Q10 might decrease blood pressure. Combining coenzyme Q10 with other herbs and supplements with that lower blood pressure might make blood pressure go too low. Some of these herbs and supplements include andrographis, casein peptides, cat's claw, fish oil, L-arginine, lycium, stinging nettle, theanine, and others.
Combining coenzyme Q10 with omega-3 fatty acids can reduce blood levels of coenzyme Q10. In theory, this might reduce the effects of coenzyme Q10.
Red yeast might reduce coenzyme Q10 levels. In theory, this might reduce the effects of coenzyme Q10.
Coenzyme Q10 can increase blood levels of vitamin A. In theory, this might increase the effects and side effects of vitamin A.
Coenzyme Q10 can increase blood levels of vitamin C. In theory, this might increase the effects and side effects of vitamin C.
Coenzyme Q10 can increase blood levels of vitamin E. In theory, this might increase the effects and side effects of vitamin E.
Coenzyme Q10 can have effects in the body that are similar to vitamin K, including inhibiting the effects of blood thinning drugs such as warfarin. Taking coenzyme Q10 with vitamin K might increase the risk of blood clotting in people taking blood thinning drugs.
There are no known interactions with foods.
Co Q10, Co Q-10, Coenzima Q-10, Co-Enzyme 10, Coenzyme Q 10, Coenzyme Q10, Co-Enzyme Q10, Co-Enzyme Q-10, Co-Q 10, CoQ10, Co-Q10, CoQ-10, Ubidcarenone, Ubidécarénone, Ubiquinone-10.
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