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Zoladex Shows Fertility Advantages in Treatment of Early Breast Cancer

At the 2014 American Society of Clinical Oncology® meeting in Chicago, researchers reported that women with early stage hormone receptor-negative (HR-negative) breast cancer who were treated with Zoladex® (goserelin) had a reduced rate of ovarian failure at 2 years. In addition, the Zoladex group had higher rates of patients becoming pregnant, patients giving birth, and patients with one or more deliveries (or still pregnant).  

HR-negative breast cancer is a type of breast cancer that does not respond to hormonal therapy, treatment that lowers the amount of estrogen in the body or blocks its action. A problem associated with the chemotherapy used to treat HR-negative breast cancer is ovarian failure (loss of function before the age of 40). 

In this study conducted with multiple research groups, premenopausal women with early stage HR-negative breast cancer were enrolled and treated with a regimen of cyclophosphamide-containing chemotherapy. Patients were then randomized to take either additional Zoladex or just chemotherapy alone. 

Researchers reported that at two years only 8% of the Zoladex patients encountered ovarian failure as compared to 22% in the chemotherapy-alone group. Other fertility measures improved as well, including pregnancies (21% versus 11%), births (15% versus 7%), and patients with one or more deliveries or still pregnant (18% versus 9%).   

Reference: Moore et al. Phase III trial (Prevention of Early Menopause Study [POEMS]-SWOG S0230) of LHRH analog during chemotherapy to reduce ovarian failure in early-stage, hormone receptor-negative breast cancer: An international intergroup trial of SWOG, IBCSG, ECOG, and CALGB. ASCO 2014; Abstract LBA505. 

 

Posted June 12, 2014