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Home > Understanding Breast Cancer > Breast Cancer Research > Table 30b: Breast cancer screening with mammography for women 50–69

  


Table 30b: Breast cancer screening with mammography for women 50–69

This summary table contains detailed information about research studies. Summary tables offer an informative look at the science behind many breast cancer guidelines and recommendations. However, they should be viewed with some caution. In order to read and interpret research tables successfully, it is important to understand some key concepts. Learn how to read a research table.

Introduction: There are clear benefits to screening mammography in women 50 to 69. Although not all of the randomized controlled trials to date have found a strong benefit, when study results are combined in meta-analyses, they show mammography in women 50 to 69 reduces breast cancer mortality (death).  

Learn more about mammography in women 50 to 69.  

Learn about the debate over mammography.  

Study selection criteria: Large randomized controlled trials and meta-analyses.

Table note: Relative risk above 1 indicates increased risk. Relative risk below 1 indicates decreased risk.  

Study 

Study Population
(number of participants) 

Follow-up
(years) 

Age at Screening 

Relative Risk of Breast Cancer Mortality (Death) in Women Who Got Screening Mammography Versus Women Who Did Not
RR (95% CI) 

Randomized controlled trials 

Ostergotland [1]

55,059

13

age 50-74

0.70 (0.62-0.80)

Kopparberg [1]

42,558

13

age 50-74

0.55 (0.42-0.73)

Canadian National Breast Screening Study [2]

39,405

25

age 50-59

1.02 (0.77-1.36)

Stockholm [1]

 38,318

 13

age 50-64

 0.64 (0.41-1.01)

Malmo I [1]

34,856

13

age 50-69

0.86 (0.64-1.16)

Malmo II [3]

34,229

17

age 50-70

0.83 (0.66-1.04)

HIP-study [3]

 33,010

18

age 50-64

0.79 (0.58-1.06)

Edinburgh [4]

32,897

14

age 50-54

1.09 (0.69-1.71)

     

age 55-59

0.71 (0.47-1.07)

     

age 60-64

0.87 (0.57-1.35)

Gothenburg [5]

 25,670

14

 age 50-54

 1.06 (0.66-1.72)

     

age 55-59

0.67 (0.43-1.06)

Meta-analyses 

Kerlikowske et al. [6]

13 studies

7-12

 age 50-74

0.77 (0.69-0.87)

Cochrane Collaboration [1] 

7 studies

13

age 50+

0.77 (0.69-0.86)*

U.S. Preventive Task Force [7]

6 studies

 

age 50-59

0.86 (0.75-0.99)

 

2 studies

 

age 60-69

0.68 (0.54-0.87)

*The combined relative risk for the two studies with good methodology was 0.94 (0.77-1.15). 

 

References 

  1. Gøtzsche PC, Nielsen M. Screening for breast cancer with mammography. Cochrane Database Syst Rev. 6:CD001877, 2013.
  2. Miller AB, Wall C, Baines CJ, Sun P, To T, Narod SA. Twenty five year follow-up for breast cancer incidence of the Canadian National Breast Screening Study: randomized screening trial. BMJ. 348:g366, 2014.
  3. Humphrey LL, Helfand M, Chan BKS, et al. Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 137(5): 347-367, 2002.
  4. Alexander FE, Anderson TJ, Brown HK, et al. 14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet. 353(9168):1903-8, 1999.
  5. Bjurstam N, Björneld L, Warwick J, et al. The Gothenburg Breast Screening Trial. Cancer. 97(10):2387-96, 2003.
  6. Kerlikowske K, Grady D, Rubin SM, et al. Efficacy of screening mammography: A meta-analysis. JAMA. 273:149-154, 1995.
  7. Nelson HD, Tyne K, Naik A, Bougatsos C, Chan BK, Humphrey L for the U.S. Preventive Services Task Force. Screening for breast cancer: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 151(10):727-37, W237-42, 2009.

Updated 05/28/14