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Targeted Therapies



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Targeted Therapies
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Breast Cancer 101 (Interactive Multimedia) - Targeted Therapy
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Research Fast Facts: Breast Cancer Therapies
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A targeted therapy is a drug designed to attack a certain molecular agent or pathway involved in the development of cancer. For example, the drug trastuzumab (Herceptin) targets a certain gene's protein called HER2/neu that is found on the surface of some cancer cells.  

Unlike chemotherapy drugs, targeted therapies kill cancer cells with little harm to healthy cells. One of the drawbacks of these therapies is they only work on cancers that have the specific markers they were designed to target. Therefore, many people cannot use these drugs.  

Targeted therapies offer promise for current and future breast cancer treatments.  

To learn more about a specific targeted therapy drug, visit the National Institutes of Health’s Medline Plus website

Trastuzumab in the adjuvant (after breast surgery) treatment of early and locally advanced breast cancer

Learn about trastuzumab in the adjuvant treatment of early and locally advanced breast cancer.

Trastuzumab and pertuzumab in the neoadjuvant (before breast surgery) treatment of early and locally advanced breast cancer

Learn about trastuzumab and pertuzumab as part of neoadjuvant treatment of early and locally advanced breast cancer.

Trastuzumab, lapatinib and other targeted therapies in the treatment of metastatic breast cancer

Learn about trastuzumab, lapatinib and other targeted therapies in the treatment of metastatic breast cancer.  

Treatment guidelines

Although the exact treatment for breast cancer varies from person to person, guidelines help ensure quality care. These guidelines are based on the latest research and the consensus of experts. The National Comprehensive Care Network (NCCN) and American Society of Clinical Oncology (ASCO) are two respected organizations that regularly update and post their guidelines online. The National Cancer Institute (NCI) also has overviews of treatment options.


 Komen Support Resources  

  • Our breast care helpline 1-877 GO KOMEN (1-877-465-6636) provides free, professional support services and help finding local support groups and resources. Our trained and caring staff are available to you and your family Monday through Friday from 9:00 a.m. to 10:00 p.m. ET and from 6:00 a.m. to 7:00 p.m. PT. 
  • Our Message Boards offer online forums for breast cancer survivors, including a forum on targeted therapies, to share their experiences and advice with other breast cancer survivors. 
  • Our fact sheets, booklets and other education materials offer additional information for survivors.  

Prescription drug assistance

Targeted therapy drug costs can quickly become a financial burden for you and your family. Medicare and many insurance providers offer prescription drug plans. One may already be included in your policy or you may be able to buy an extra plan for prescriptions.  

You may also qualify for assistance from programs that help with drug costs or offer low-cost or free prescriptions.  

Learn more about insurance plans and prescription drug assistance programs.  

Susan G. Komen® position on fairness in breast cancer medication coverage  

Medications taken by mouth (oral) are usually covered under a health insurance plan’s prescription drug benefit rather than the plan’s medical benefit. As a result, people often find themselves facing high out-of-pocket costs when filling their prescriptions (sometimes costing thousands of dollars per month). High prescription drug costs are a barrier to care. High costs can prevent people from getting the medications prescribed by their health care provider.

Komen supports efforts at the state and federal level to require insurers to provide equal (or better) coverage for oral breast cancer medications as they provide for IV medications to ensure people have access to affordable, appropriate treatment for their cancer.

Updated 05/02/14



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