> Table 30b: Breast cancer screening with mammography for women 50–69
This summary table contains detailed information about research studies. Summary tables offer an informative look at the science behind many breast cancer guidelines and recommendations. However, they should be viewed with some caution. In order to read and interpret research tables successfully, it is important to understand some key concepts. Learn how to read a research table.
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Introduction: There are clear benefits to screening mammography in women 50 to 69. Although not all of the randomized controlled trials to date have found a strong benefit, when study results are combined in meta-analyses, they show mammography in women 50 to 69 reduces breast cancer mortality (death).
Learn more about mammography in women 50 to 69.
Learn about the debate over mammography.
Study selection criteria: Large randomized controlled trials and meta-analyses.
Table note: Relative risk above 1 indicates increased risk. Relative risk below 1 indicates decreased risk.
Study
|
Study Population
(number of participants)
|
Follow-up
(years)
|
Age at Screening
|
Relative Risk of Breast Cancer Mortality in Women who Were Screened with Mammography versus Women
who Were Not
RR (95% CI)
|
Randomized controlled trials
|
Ostergotland [1]
|
55,059
|
13
|
age 50-74
|
0.70 (0.62-0.80)
|
Kopparberg [1]
|
42,558
|
13
|
age 50-74
|
0.55 (0.42-0.73)
|
CNBSS-2 [2]
|
39,405
|
13
|
age 50-59
|
1.02 (0.78-1.33)
|
Stockholm [1]
|
38,318
|
13
|
age 50-64
|
0.64 (0.41-1.01)
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Malmo I [1]
|
34,856
|
13
|
age 50-69
|
0.86 (0.64-1.16)
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Malmo II [3]
|
34,229
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16.9
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age 50-70
|
0.83 (0.66-1.04)
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HIP-study [3]
|
33,010
|
18
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age 50-64
|
0.79 (0.58-1.06)
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Edinburgh [4]
|
32,897
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14
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age 50-54
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1.09 (0.69-1.71)
|
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age 55-59
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0.71 (0.47-1.07)
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|
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age 60-64
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0.87 (0.57-1.35)
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Gothenburg [5]
|
25,670
|
14
|
age 50-54
|
1.06 (0.66-1.72)
|
| |
|
|
age 55-59
|
0.67 (0.43-1.06)
|
Meta-analyses
|
Kerlikowske et al. [6]
|
13 studies
|
7-12
|
age 50-74
|
0.77 (0.69-0.87)
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Cochrane Collaboration [1]
|
7 studies
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13
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age 50+
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0.77 (0.69-0.86)*
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U.S. Preventive Task Force [7]
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6 studies
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age 50-59
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0.86 (0.75-0.99)
|
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2 studies
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age 60-69
|
0.68 (0.54-0.87)
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*The combined relative risk for the two studies with good methodology was 0.94 (0.77-1.15).
References
- Gøtzsche PC, Nielsen M. Screening for breast cancer with mammography. Cochrane Database Syst Rev. (1):CD001877, 2011.
- Miller AB, To T, Baines CJ, Wall C. Canadian National Breast Screening Study-2: 13-year results of a randomized trial in women aged 50-59 years. J Natl Cancer Inst. 92(18):1490-9, 2000.
- Humphrey LL, Helfand M, Chan BKS, et al. Breast cancer screening: a summary of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine. 137(5): 347-367, 2002.
- Alexander FE, Anderson TJ, Brown HK, et al. 14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening. Lancet. 353(9168):1903-8, 1999.
- Bjurstam N, Björneld L, Warwick J, et al. The Gothenburg Breast Screening Trial. Cancer. 97(10):2387-96, 2003.
- Kerlikowske K, Grady D, Rubin SM, et al. Efficacy of screening mammography: A meta-analysis. JAMA. 273:149-154, 1995.
- Nelson HD, Tyne K, Naik A, Bougatsos C, Chan BK, Humphrey L for the U.S. Preventive Services Task Force. Screening for breast cancer: an update for the U.S. Preventive Services Task Force. Ann Intern Med. 151(10):727-37, W237-42, 2009.
Updated 06/01/12
