This summary table contains detailed information about research studies. While viewing summary tables offers an informative glimpse at the science behind many breast cancer guidelines and recommendations, they should be viewed with some caution. There are a number of concepts you must understand to be able to successfully read and interpret research tables. To get some background information about understanding research tables, please see How to Read a Research Table.
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Introduction: The body of scientific evidence shows the use of permanent hair dye does not increase the risk of breast cancer. Prospective cohort studies, case-control studies and a meta-analysis of 14 studies have found no link between hair dye and breast cancer risk.
Find more information on the strengths and weaknesses of different types of studies.
See how this risk factor compares with other risk factors for breast cancer.
Study selection criteria: Available prospective cohort studies, case-control studies and meta-analyses.
Table note: Relative risk above 1 indicates increased risk. Relative risk below 1 indicates decreased risk.
Study
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Study Population
(number of participants)
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Follow-up (years)
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Relative Risk of Breast Cancer in Women Who Have Ever Used Hair Dye Compared to Those Who Have Never Used Hair Dye, RR (95% CI)
|
Prospective cohort studies
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Thun et al. [1]
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573,369
|
7
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0.95 (0.83-1.08)
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Green et al. [2]
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118,404
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6
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1.1 (0.9-1.2)
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Case-control studies
|
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Cases
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Controls
|
|
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Nasca et al. [3]
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1,617
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1,617
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NA
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1.04 (0.90-1.21)
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Cook et al. [4]
|
844
|
960
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NA
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1.3 (1.0-1.6)
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Zheng et al. [5]
|
608
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609
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NA
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0.9 (0.7-1.2)
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Wynder et al. [6]
|
401
|
625
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NA
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1.02 (0.77-1.32)
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Koenig et al. [7]
|
398
|
790
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NA
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0.8 (0.6-1.1)
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Kinlen et al. [8]
|
191
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561
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NA
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1.01NS
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Shore et al. [9]
|
129
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193
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NA
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1.44NS
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Nasca et al. [10]
|
118
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233
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NA
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0.98 (0.58-1.66)
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Stavraky et al. [11]*
|
36
|
63
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NA
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1.5 (0.7-3.1)
|
| |
21
|
47
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NA
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0.7 (0.3-1.7)
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Meta-analyses
|
Takkouche et al. [12]
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14 studies including 680,633 women
(overall use of hair dyes)
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NA
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1.06 (0.95-1.18)
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9 studies
(permanent hair dye use only)
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NA
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0.98 (0.91-1.07)
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9 studies
(intensive hair dye use)
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NA
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0.99 (0.89-1.11)
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NS = Not statistically significant.
* Study results from each of two different study sites.
References
1. Thun MJ, Altekruse SF, Namboodiri MM, et al. Hair dye use and risk of fatal cancer in U.S. women. J Natl Cancer Inst. 86(3):210-215, 1994.
2. Green A, Willett WC, Colditz GA, et al. Use of permanent hair dyes and risk of breast cancer. J Natl Cancer Inst. 79(2):253-257, 1987.
3. Nasca PC, Baptiste MS, Field NA, et al. An epidemiologic case-control study of breast cancer and exposure to hair dyes. Ann Epidemiology. 2(5):577-586, 1992.
4. Cook LS, Malone KE, Daling JR, et al. Hair product use and the risk of breast cancer in young women. Cancer Causes Control. 10(6):551-559, 1999.
5. Zheng T, Holford TR, Mayne ST, Owens PH, Boyle P, Zhang B, Zhang YW, Zahm SH. Use of hair colouring products and breast cancer risk: a case-control study in Connecticut. Eur J Cancer. 38(12):1647-52, 2002.
6. Wynder EL and Goodman M. Epidemiology of breast cancer and hair dye. J Natl Cancer Inst. 71(3): 481-488, 1983.
7. Koenig KL, Pasternack BS, Shore RE, et al. Hair dye use and breast cancer: a case-control study among screening participants. Am J Epidemiol. 133(10):985-995, 1991.
8. Kinlen LJ, Harris R, Garrod A, et al. Use of hair dyes by patients with breast cancer: a case-control study. Br Med J. 2 (6083):366-368, 1977.
9. Shore RE, Pasternack BS, Thiessen EU, et al. A case-control study of hair dye use and breast cancer risk. J Natl Cancer Inst. 62(2):277-283, 1979.
10. Nasca PC, Lawrence CE, Greenwald P, et al. Relationship of hair dye use, benign breast disease, and breast cancer. J Natl Cancer Inst. 64(1): 23-28, 1980.
11. Stavraky KM, Clarke EA, Donner A. Case-control study of hair dye use by patients with breast cancer and endometrial cancer. J Natl Cancer Inst. 63(4):941-945, 1979.
12. Takkouche B, Etminan M, Montes-Martinez A. Personal use of hair dyes and risk of cancer: a meta-analysis. JAMA. 293(20):2516-25, 2005.
Updated 09/12/09
