Shiitake mushroom is a fungus. An extract made from this mushroom is used as medicine.
Shiitake mushroom is used for boosting the immune system, lowering blood cholesterol levels, treating prostate cancer, and as an anti-aging agent.
Shiitake mushroom is also eaten as food.
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
The effectiveness ratings for SHIITAKE MUSHROOM are as follows:
More evidence is needed to rate the effectiveness of shiitake mushroom for these uses.
Shiitake mushroom is LIKELY SAFE when consumed by mouth in food amounts, but it seems POSSIBLY UNSAFE to take by mouth in medicinal amounts. It can cause stomach discomfort, blood abnormalities, and skin swelling (inflammation). It might also cause an increased sensitivity to the sun, allergic skin reactions, and breathing problems.
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking shiitake mushroom if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Shiitake mushroom might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using shiitake mushroom.
A blood disorder called eosinophilia: Don’t use shiitake mushroom if you have this condition. It might make eosinophilia worse.
Interaction Rating = Moderate Be cautious with this combination.
Talk with your health provider.
Shiitake mushroom seems to increase the immune system. By increasing the immune system, shiitake mushroom might decrease the effectiveness of medications that decrease immune system function.
Some medications that decrease immune system function include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
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