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Niacin

 

Natural Standard Monograph, Copyright © 2014 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified health care professional before making decisions about therapies and/or health conditions.

Related Terms

  • 2-pyridone, 3-pyridine carboxamide, acipimox (5-methylpyrazinecarboxylic acid 4-oxide), acipomox, Acipimox®, anti-blacktongue factor, antipellagra factor, B vitamin, B-complex vitamin, benicot, B-vitamin, chromium polynicotinate (niacin-bound chromium), coenzyme beta-nicotinamide adenine dinucleotide (NAD(+)), crystalline niacin, dihydropyridines, Efacin®, Endur-Acin® (sustained release niacin (nicotinic acid)), Enduramide®, ER niacin, esters of niacin, extended-release (ER) niacin, extended-release (ER) niacin monotherapy, extended-release (ER) niacin therapy, Hexopal®, immediate-release (crystalline) niacin, immediate-release niacin, inositol hexaniacinate, inositol hexanicotinate, inositol nicotinate, kynurenine (KYN), low-dose sustained-release nicotinic acid (Tri-B3), meso-inositol hexanicotinate, methyl niacinamide, Nature's Bounty® Flush Free Niacin Inositol Hexanicotinate 500mg Dietary Supplement, NIAC®, niacin, niacin (nicotinic acid), niacin equivalents, niacin ER, niacinamide, niacinamide adenine dinucleotide (NAD), niacinamide adenine dinucleotide phosphate (NADP), niacin/colestipol therapy, Niacor®, Niaspan® (prolonged-release nicotinic acid), Niaspan® (sustained-release nicotinic acid), Nicalex®, nicamid, Nicamin®, Nicangin®, Niceritrol, Nico-400®, Nicobid® (sustained-released niacin), Nicobid® (time-release niacin), Nicolar® (unmodified niacin), nicosedine, Nico-Span®, nicotinamide, nicotinamide (niacinamide), Nicotinamide cures, nicotinate, Nicotinex®, nicotinic acid, nicotinic acid adenine, nicotinic acid adenine dinucleotide phosphate (NAADP), nicotinic acid amide, nicotinic acid analog (low plasma free fatty acid trial, LFA), nicotinic acid analogue, nicotinic amide, nicotinuric acid, nicotylamidum, nutrient supplements, Papulex®, pellagra preventing factor, pentaerythritoltetranicotinate, perycit, prolonged-release (PR) nicotinic acid (niacine)[Niaspan®], pyridine-3-carboxylic acid, Slo-Niacin® (sustained-release niacin), sustained-release nicotinic acid (Nico-Span®), Tega-Span®, Tri-B3®, trigonelline, tryptophan, vitamin B-3, vitamin B3, vitamin B3 (nicotinamide), vitamin B3 derivative, vitamin-B complex (vit-B), Wampocap®, wax-matrix sustained release niacin, wax-matrix sustained-release niacin (Endur-Acin®).
  • Combination product examples: ADVICOR® (niacin extended-release/lovastatin tablets), CordaptiveTM (niacin/laropiprant).

Background

  • Vitamin B3 is made up of niacin and niacinamide, and can be found in many foods, including yeast, meat, fish, milk, eggs, green vegetables, and cereal grains. Vitamin B3 is often found in combination with other B vitamins, including thiamine, riboflavin, pantothenic acid, pyridoxine, cyanocobalamin, and folic acid.
  • The U.S. Food and Drug Administration (FDA) has approved niacin for use in treating vitamin B3 deficiency (pellagra), which includes symptoms of skin inflammation, dementia, and diarrhea.
  • Human research has shown that niacin is effective and relatively safe for treating high cholesterol levels. Limited evidence shows that niacin may help with clogged arteries and heart disease. Side effects commonly related to higher doses of niacin are itching, flushing, and stomach upset. Niacin may also cause liver problems, increased blood sugar, and hormone changes.

Evidence

 

Uses based on scientific evidence 

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare professional.

Grade* 

High cholesterol 

Niacin is a well-accepted treatment for high cholesterol. Multiple studies show that niacin (not niacinamide) has benefits on levels of high-density cholesterol (HDL or "good cholesterol"), with better results than drugs such as "statins" like atorvastatin (Lipitor®). There are also benefits on levels of low-density cholesterol (LDL or "bad cholesterol"), although these effects are less dramatic. Adding niacin to a second drug such as a statin may increase the effects on low-density lipoproteins. The use of niacin for the treatment of high cholesterol associated with type 2 diabetes has been controversial because of the possibility of worsening blood sugar control. People should check with a physician and pharmacist before starting niacin.

A 

Pellagra 

Niacin (vitamin B3) and niacinamide are U.S. Food and Drug Administration (FDA)-approved for the treatment of pellagra, or niacin deficiency. Pellagra is a nutritional disease that occurs due to insufficient dietary amounts of vitamin B3 or the chemical it is made from (tryptophan). Symptoms of pellagra include skin disease, diarrhea, dementia, and depression.

A 

Clogged arteries 

Niacin decreases blood levels of cholesterol, which may reduce the risk of clogged or hardened arteries. However, niacin also can increase homocysteine levels, which may have the opposite effect. Overall, the research supports the use of niacin in combination with other drugs to reduce the risk of clogged arteries. More research is needed in this area before a firm conclusion can be drawn.

B 

Heart disease 

Niacin decreases levels of cholesterol, and other chemicals in the blood, which can reduce the risk of heart disease. However, niacin also increases homocysteine levels, which can increase this risk. Research has shown beneficial effects of niacin, especially in combination with other drugs, for preventing heart disease and fatal heart attacks. Further study is needed to draw conclusions.

B 

Age-related macular disease (eye disease) 

Early evidence suggests that niacin may have beneficial effects in age-related macular degeneration (AMD), a disease that often leads to vision loss. More well-designed studies are needed for conclusions to be reached.

C 

Alzheimer's disease (mental decline) 

Dementia can be caused by a severe lack of niacin in the body. Early evidence suggests that taking more niacin in the diet may slow the onset of Alzheimer's disease and mental decline. Further research is needed before a conclusion can be drawn.

C 

Erectile dysfunction 

Early research suggests that niacin has a beneficial effect on erectile dysfunction. However, further well-controlled studies are needed to draw conclusions.

C 

Headaches 

Early research shows that niacin may be beneficial in the treatment or prevention of headaches. More research is needed.

C 

Hepatitis C 

Early research suggests that niacin may decrease blood levels of hepatitis C, a virus that damages the liver. Notably, niacin has been also associated with liver damage. Further research is necessary for a conclusion to be made.

C 

High blood phosphorous level 

Early evidence shows that niacinamide had reduced high phosphate levels in the blood. However, more research is needed before a firm conclusion can be made.

C 

Osteoarthritis (niacinamide) 

Early research suggests that niacinamide may be useful in the treatment of osteoarthritis. Further research is needed before a conclusion can be made.

C 

Skin conditions 

Niacinamide has been used in skin care products, including moisturizers, anti-aging products, and treatments for rosacea, a skin condition involving facial redness and pimples. The benefits of niacinamide in skin care needs to be further studied before conclusions can be made.

C 

Type 1 diabetes (slowing progression) 

Non-human research shows that niacinamide delays the onset of insulin dependence in type 1 diabetes. However, human research assessing whether niacinamide slows progression of type 1 diabetes has yielded unclear results. Further study is needed for conclusions to be reached.

C 

Type 2 diabetes 

Limited research shows unclear effects of niacin on outcomes of type 2 diabetes. Human research has also shown that niacin increases blood sugar levels. People should seek medical advice before starting niacin. Further research is needed to draw conclusions.

C 

Type 1 diabetes mellitus prevention (niacinamide) 

In human research, niacinamide lacked an effect on the development of diabetes (type 1). Evidence is mixed and more study is needed in this area.

D 

 

*Key to grades: 

A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use (it may not work);
F: Strong scientific evidence against this use (it likely does not work).

For full grading rationale, click here.

Uses based on tradition or theory 

The below uses are based on tradition or scientific theories. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified health care professional

Alcohol dependence, anemia (lack of red blood cells), anti-aging, antioxidant, anxiety, arthritis, Bell's palsy (face paralysis), blood thinner, bone marrow suppression (results in decreased blood cells), breast cancer, bursitis (joint inflammation), cancer prevention, cancer treatment side-effects, cataract prevention, chest pain, chronic diarrhea/hypokalemia (long-term diarrhea resulting in low potassium levels), circulatory/blood flow disorders, coronary artery (heart) disease, cosmetic uses, dementia (confusion), depression, diabetes mellitus (type 1) treatment, diabetic complications (high cholesterol), diarrhea, digestion improvement, dizziness, drug-induced hallucinations, swelling, encephalopathy (brain disease), erythema induratum (skin disorder), glossitis (inflamed tongue), growth, heart attack prevention, hearing loss, hepatic encephalopathy (confused thinking due to liver disorders), high blood pressure, HIV, hyperactivity (abnormally active), hyperkinesis (excessive movement), infectious diarrhea (choleric), insomnia, intermittent claudication (leg pain from clogged arteries), ischemia-reperfusion injury prevention (protection from injury caused by lack of blood flow), itching, leprosy (fatal infection), liver disease, liver cancer, lupus (cholesterol abnormalities), memory enhancement, Meniere's syndrome (inner ear disorder), menstrual pain, metabolic syndrome, migraine headache, motion sickness, multiple sclerosis (disease of the nervous system), nervous system disorders, nutrition, obesity (too much body fat), pain, painful menstruation, pancreatitis (inflamed pancreas), parasite infection, Parkinson's disease, peripheral vascular disease (blocked arteries in the legs), polymorphous light eruption (skin disorder due to sunlight), pregnancy, premenstrual syndrome (PMS), prostate cancer, psoriasis, psychosis, Raynaud's disease (reduced blood flow to extremities), ringing in the ears, schizophrenia (for identifying the disease), scleroderma (scar tissue build-up on skin), sedative, seizure disorder, sexual arousal (orgasm improvement), skin inflammation, sleep quality, smoking cessation, stroke, sun protection, swelling, tardive dyskinesia (involuntary movements), taste disturbances, thyroid disorders, tuberculosis, vasculitis (erythema diutinum), ulcers, vascular spasm (blood vessels), vertigo, wound healing.


Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare professional before starting a new therapy. Consult a healthcare professional immediately if you experience side effects.

Allergies

  • Avoid in people with known allergy or sensitivity to niacin, niacinamide, or products containing one or both of these products.
  • Rarely, anaphylactic shock (severe allergic reaction) has been described after giving niacin by mouth or injecting it into the vein.

Side Effects and Warnings

  • Niacin is likely safe when taken by mouth daily in recommended amounts under the supervision of a qualified healthcare provider. Homocysteine levels should be monitored.
  • Niacin or niacinamide may result in the following side effects: abnormal heart rhythms, ascites (fluid build-up in the gut lining), blurred vision, build-up of lactic acid in the body, bleeding disorders, changes in liver structure, changes in thyroid hormones, decreased platelets, decreased fibrinogen (chemical that helps clotting), decreased white blood cells, diarrhea, displacement of the eye, dizziness, dry eyes, dry skin, eye disease, eye swelling, eyebrow and eyelash discoloration, failure of blood circulation, fainting, flushing, headache, heartburn, hernia, hypothyroidism (under-active thyroid), increased blood volume in the eye, increased heartbeat, increased creatine kinase, increased homocysteine levels, increased insulin resistance, increased insulin in the blood, increased liver enzymes, increased risk of muscle breakdown, increased uric acid levels in the blood, increased eosinophils (a white blood cell), inflammation of the cornea of the eye, insulin resistance, itching, jaundice (yellowing of the skin), liver adverse effects, liver damage, liver inflammation, liver failure, loss of eyebrows and eyelashes, migraine, muscle disease, nausea, pain in the gums and teeth, panic, peptic ulcer disease, rash, stomach upset, sugar and ketones in the urine, swelling, vision loss due to toxic reactions, vomiting, and warm sensations.
  • Niacin may increase blood sugar levels. Caution is advised in people with diabetes who are not monitored by a qualified healthcare provider and in those taking drugs, herbs, or supplements that affect blood sugar. Blood sugar levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.
  • Niacin may increase the risk of bleeding. Caution is advised in people with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.
  • Use cautiously in people with kidney disorders and gout.
  • Use cautiously in children.
  • Avoid in people with sensitivity to niacin, niacinamide, or products containing one or both of these products.
  • Avoid in people with liver dysfunction or disease, peptic ulcer disease, or arterial bleeding.

Pregnancy and Breastfeeding

  • There is a lack of research regarding the use of niacin during pregnancy and breastfeeding.

Interactions

Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare professional before starting a new therapy.

Interactions with Drugs

  • Niacin may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
  • Niacin may increase blood sugar levels. Caution is advised when using medications that may alter blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
  • Niacin may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.
  • Niacin may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be altered in the blood, and may cause altered effects or potentially serious adverse reactions. People using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.
  • Niacin may also interact with agents for the heart, agents that widen blood vessels, agents used for the liver, agents used for seizures, alcohol, androgens, antibiotics, antigout agents, antihistamines, antithyroid agents, aspirin, benzodiazepines, birth control taken by mouth, calcium-channel blockers, cholesterol-lowering agents (bile acid sequestrants, fibrates, HMG-CoA reductase inhibitors), epinephrine, estrogens, ganglionic blocking drugs, griseofulvin, neomycin, nicotine, nonsteroidal anti-inflammatory drugs (NSAIDs), primidone, probucol, procetofene, progestins, pyrazinamide, theophylline, and thyroid hormones.

Interactions with Herbs and Dietary Supplements

  • Niacin may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
  • Niacin may increase blood sugar levels. Caution is advised when using herbs or supplements that may alter blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
  • Niacin may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.
  • Niacin may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be altered in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.
  • Niacin may also interact with amino acids, androgens, antibacterials, antigout herbs and supplements, antihistamines, antioxidants, antithyroid herbs and supplements, cholesterol-lowering herbs and supplements, chromium, coffee, ganglionic blocking herbs and supplements, grape seed, herbs and supplements for the heart, herbs and supplements that widen blood vessels, herbs and supplements used for the liver, herbs and supplements used for birth control, herbs and supplements used for seizures, inositol hexanicotinate, kava, minerals, pantothenic acid, phytoestrogens, phytoprogestins, salicylate-containing herbs, sitosterols, sorghum, thyroid hormones, tryptophan, vitamins E, A, and B6, and zinc sulfate.

Authors

Selected References

Natural Standard developed the above evidence-based information based on a systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.

  1. Balasubramanyam A, Coraza I, Smith EO, et al. Combination of niacin and fenofibrate with lifestyle changes improves dyslipidemia and hypoadiponectinemia in HIV patients on antiretroviral therapy: results of "heart positive," a randomized, controlled trial. J.Clin.Endocrinol.Metab 2011;96(7):2236-2247.
  2. Betteridge DJ. Lipid control in patients with diabetes mellitus. Nat.Rev.Cardiol. 2011;8(5):278-290.
  3. Boden WE, Probstfield JL, Anderson T, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. N.Engl.J.Med. 12-15-2011;365(24):2255-2267.
  4. Chapman MJ, Redfern JS, McGovern ME, et al. Niacin and fibrates in atherogenic dyslipidemia: pharmacotherapy to reduce cardiovascular risk. Pharmacol.Ther. 2010;126(3):314-345.
  5. Daniels SE, Spivey RJ, Singla S, et al. Efficacy and safety of oxycodone HCl/niacin tablets for the treatment of moderate-to-severe postoperative pain following bunionectomy surgery. Curr.Med.Res.Opin. 2011;27(3):593-603.
  6. Dunatchik AP, Ito MK, and Dujovne CA. A systematic review on evidence of the effectiveness and safety of a wax-matrix niacin formulation. J.Clin.Lipidol. 2012;6(2):121-131.
  7. Henriquez-Sanchez P, Sanchez-Villegas A, Doreste-Alonso J, et al. Dietary assessment methods for micronutrient intake: a systematic review on vitamins. Br.J.Nutr. 2009;102 Suppl 1:S10-S37.
  8. Ito MK. Dyslipidemia: management using optimal lipid-lowering therapy. Ann.Pharmacother. 2012;46(10):1368-1381.
  9. Ng CF, Lee CP, Ho AL, et al. Effect of niacin on erectile function in men suffering erectile dysfunction and dyslipidemia. J.Sex Med. 2011;8(10):2883-2893.
  10. Orr KK and Hume AL. An evidence-based update on vitamins. Med.Health R.I. 2010;93(4):122-124.
  11. Prasad V and Vandross A. Cardiovascular primary prevention: how high should we set the bar? Arch.Intern.Med. 4-23-2012;172(8):656-659.
  12. Robinson JG, Wang S, and Jacobson TA. Meta-analysis of comparison of effectiveness of lowering apolipoprotein B versus low-density lipoprotein cholesterol and nonhigh-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trials. Am.J.Cardiol. 11-15-2012;110(10):1468-1476.
  13. Shaikh Q and Kamal AK. HDL cholesterol--how do I raise my patients good cholesterol? J.Pak.Med.Assoc. 2012;62(6):623-624.
  14. Troesch B, Hoeft B, McBurney M, et al. Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries. Br.J.Nutr. 2012;108(4):692-698.
  15. Yadav R, France M, Younis N, et al. Extended-release niacin with laropiprant : a review on efficacy, clinical effectiveness and safety. Expert.Opin.Pharmacother. 2012;13(9):1345-1362.
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