Breast cancer risk reduction and risk assessment are active areas of research.
Some studies are looking at ways to reduce risk in women at higher risk of breast cancer, such as new risk-lowering drugs.
Other studies are focused on new and better ways of knowing which women are at higher risk.
Some drugs used to treat breast cancer are under study for their use in risk reduction for women at higher risk.
New risk-lowering drugs are also being developed.
Learn about FDA-approved drugs for lowering the risk of breast cancer.
Aromatase inhibitors are hormone drugs that are used to treat estrogen receptor-positive breast cancer in postmenopausal women.
Anastrozole (Arimidex), letrozole (Femara) and exemestane (Aromasin) are aromatase inhibitors.
These drugs are being studied to see whether they may lower breast cancer risk in postmenopausal women at high risk.
Findings from randomized controlled trials of postmenopausal women at high risk have shown the aromatase inhibitors exemestane and anastrozole may lower the risk of breast cancer by about half [177,283].
Unlike tamoxifen and raloxifene, exemestane and anastrozole do not appear to increase the risk of blood clots [177,283]. However, they can cause menopausal symptoms, a loss of bone density and other side effects [284-287].
The American Society for Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN) list exemestane and anastrozole as risk-lowering drug options for postmenopausal women at higher risk of breast cancer.
However, these drugs do not yet have FDA-approval for use in the risk reduction setting. These drugs are only FDA-approved for use in breast cancer treatment.
Learn about aromatase inhibitors (including exemestane and anastrozole) and breast cancer treatment.
Learn more about the side effects of aromatase inhibitors.
The aromatase inhibitor drug letrozole is also being studied to see whether it may lower risk in postmenopausal women at high risk of breast cancer.
Learn about aromatase inhibitors and breast cancer treatment.
Lasofoxifene is an osteoporosis drug similar to tamoxifen and raloxifene.
Early findings suggest lasofoxifene may reduce the risk of estrogen receptor-positive breast cancer in women at risk for osteoporosis [291-292]. More data are needed to confirm these findings.
If you are at higher risk of breast cancer and considering joining a clinical trial of risk-lowering drugs, we encourage you to discuss the potential risks and benefits with your health care provider.
BreastCancerTrials.org in collaboration with Susan G. Komen offers a custom matching service to help you find a clinical trial on risk reduction for healthy women and women at high risk of breast cancer.
Learn about clinical trials.
Methods to assess breast cancer risk currently under study include :
These procedures remove cells from the breast.
A pathologist looks at the cells under a microscope. Abnormal (atypical) cells may be linked to an increased risk of breast cancer.
The procedures differ in how the cells are removed from the breast.
Ductal lavage uses a small tube to flush out fluid from the nipple. This fluid contains breast cells.
This procedure causes some discomfort.
Ductal lavage has not yet been shown to be effective for breast cancer risk assessment .
However, it is becoming more common in the U.S. and many breast centers now offer it to women at higher risk.
More research is needed to learn how to use the findings from ductal lavage.
Nipple aspiration (such as the HALO test) uses a breast pump (and sometimes massage) to remove fluid from the nipple.
Nipple aspiration has not yet been shown to be effective for breast cancer risk assessment .
More research is needed to learn how to use the findings from nipple aspiration.
RPFNA uses a thin needle to remove cells from about 10 areas near the areola.
This procedure is more invasive and causes more discomfort than ductal lavage, nipple aspiration or fine needle aspiration done for diagnosis.
RPFNA is mostly offered in clinical studies.
At this time, findings from ductal lavage, nipple aspiration or RPFNA should not affect a woman's decision to take risk-lowering drugs (tamoxifen or raloxifene), get preventive surgery or join a risk reduction clinical trial.
They should also not be used to assess risk for use in breast cancer screening recommendations.
More research is needed to learn how to best use the findings from these tests.
If you are interested in one of these tests, talk with your health care provider. He or she may be able to give you a referral to a breast center with expertise in risk assessment and risk reduction.
Ductal lavage, nipple aspiration and RPFNA are under study for risk assessment.
Risk assessment is not breast cancer screening (tests to find cancer early).
In 2013, the U.S. Food and Drug Administration issued an alert warning people that tests such as nipple aspiration should never be used as a substitute for mammography and other breast cancer screening tools .
Our commitment to research
At Susan G. Komen©, we are committed to saving lives by meeting the most critical needs in our communities and investing in breakthrough research to prevent and cure breast cancer. Our Research Program is an essential driving force for achieving this mission. Since our inception in 1982, Komen has provided funding to support research grants that have greatly expanded our knowledge of breast cancer and helped us understand that breast cancer is not just a single disease but many diseases, unique to each individual. Going forward, our commitment to research will contribute significantly to our ability to achieve our bold goal of reducing the current number of breast cancer deaths in the U.S. by 50 percent by 2026.
To date, Komen has provided more than $920M to researchers in 48 states and 21 countries to support research that has resulted in a better understanding of breast cancer; earlier detection; personalized, less invasive treatments for what was once a “one-treatment-fits-all” disease; and improvements in both quality of life and survival rates.
Learn more about our continuing investment in research and the exciting research that we are funding, because nothing would make us happier than ending breast cancer forever.
Facts for Life: Clinical Trials