Susan G Komen  
I've Been Diagnosed With Breast Cancer Someone I Know Was Diagnosed Share Your Story Join Us And Stay Informed Donate To End Breast Cancer
    Home > Research & Grants > Grants Program > Research Grants > Research Grants Awarded > Abstract
    Awarded Grants
    Green Tea Intervention for Weight Gain Prevention among Women with Breast Cancer

    Scientific Abstract:
    Green Tea Intervention for Weight Gain Prevention among Women with Breast Cancer Background. Obesity has been positively associated with an increased risk of recurrence and a higher hazard of death in breast cancer survivors. Weight gains of 2-6 kilograms have been associated with chemotherapy for breast cancer and weight control counseling, although somewhat effective, has not achieved the weight stabilization desired and can be overly burdensome for some women. Objectives/Hypothesis. We hypothesize that a simplified diet intervention, using green tea, can significantly prevent weight gain during chemotherapy. Further we intend to answer the following research questions: i. Can a green tea intervention during and after chemotherapy prevent weight gain? ii. Can regular, daily intake of green tea improve glucose-insulin regulation resulting in lower circulating levels of insulin-like growth factor-1 (IGF-1) and increase in insulin growth factor binding protein-3 (IGFBP-3)? iii. Can the green tea intervention we are implementing improve quality of life and cognitive function among women undergoing chemotherapy for Stage I or II breast cancer? Specific Aims: i. Determine if intake of 4 cups of defined green tea beverage daily for twelve months will prevent weight gain and increase metabolic rate during and post chemotherapy. ii. Determine if intake of 4 cups defined green tea beverage daily for twelve months will reduce circulating levels of IGF-I and increase IGFBP-3. iii. Determine if intake of 4 cups of defined green tea beverage daily for 12 months will improve quality of life and/or cognitive function. Study Design. We propose a randomized, double-blind, placebo-controlled green tea intervention trial among women who are undergoing chemotherapy for Stage I or II breast cancer. Seventy pre and postmenopausal women will be randomly assigned to consume 4 cups/day of green tea or placebo tea for 12 months. Endpoints include: i. Body weight, BMI, percent body fat, lean body mass, waist:hip ratio, ii. Energy balance as measured by resting metabolic rate, and self-reported physical activity and dietary intake measurement, iii. Biomarkers associated with breast cancer progression: IGF-1 and IGFBP–3, iv. Patient-reported quality of life and cognitive function including SF 36 and FACT-G. Potential Outcomes and Benefits. Prevention of weight gain has the potential to significantly improve health status, quality of life and long-term disease-free survival among women receiving chemotherapy for breast cancer. A high green tea intervention is a safe and easily adopted strategy for achieving energy balance and subsequent weight control among breast cancer patients. Moreover, green tea has the potential to improve glucose-insulin hemostasis, quality of life and cognitive function.

    Lay Abstract:
    Green Tea Intervention for Weight Gain Prevention among Women with Breast Cancer Breast cancer patients requiring chemotherapy to treat their tumors frequently gain weight during therapy. The weight gained is of particular concern because it has generally been shown to be related to an increase in body fat and a loss of lean or muscle mass which in turn may increase risk of breast cancer recurrence. Efforts to control weight gain during chemotherapy have generally focused on low fat or energy-restricted diets with or without additional counseling to increase physical activity. These approaches have had minimal success and many breast cancer patients find these approaches to weight control demanding physically, emotionally and mentally at the time when coping skills are already being challenged. We are proposing a novel approach to weight maintenance during and after chemotherapy. Seventy women with Stage I or II breast cancer who will receive chemotherapy as part of their treatment plan will be randomly assigned to four cups/day of either green tea or placebo tea for 12 months to determine if a green tea intervention will prevent weight gain during and six months after chemotherapy. Previous studies suggest that green tea can increase resting metabolic rate and potentially reduce food intake and thus may be an effective and practical approach to weight control when consumed as part of a well balanced diet. Women will be assessed for changes in body weight, body composition, quality of life and cognitive function. In addition, blood levels of certain markers of glucose-insulin balance will be measured in an effort to determine one important mechanism by which green tea could protect against breast cancer recurrence. Women will receive information related to body composition at the end of the study. Both pre and postmenopausal women will be eligible to participate in this study. Prevention of weight gain during and after chemotherapy has the potential to significantly improve health status, quality of life and long-term disease-free survival among women receiving chemotherapy for breast cancer. Tea is a promising agent because regular tea consumption is likely to be easily adopted by breast cancer patients wishing to change their lifestyle to reduce disease recurrence and improve overall health.